The UK has committed to reduce its footprint overseas. Addressing the impacts of supply chains on nature, people and climate will be central to discussions in the run-up to the United Nations Framework Convention on Climate Change (UNFCCC) Conference of the Parties 26 (CoP26), including the Forest, Agriculture and Commodity Trade (FACT) Dialogue. To assist these discussions, we provide: (1) a compilation of learnings from initiatives on the ground to halt deforestation and/or conversion, emphasising the key elements for success, such as multi-stakeholder involvement, political leadership and finance; (2) a list of geographies linked to UK trade where action is most urgent, such as the Brazilian Amazon, the Cerrado, the Gran Chaco, Côte d’Ivoire and Kalimantan (Indonesian Borneo); (3) a summary of the opportunities and challenges for the UK, such as the global processes on climate (UNFCCC CoP26) and on biodiversity (Convention on Biological Diversity (CBD) CoP15); (4) a series of case studies from some of the above-mentioned geographies with insights on how to implement, improve and/or upscale actions to generate wider benefits to nature, climate and people.